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Third, we performed a subgroup analysis by ethnicity, source of control, HWE, but the other factors, such as gender, age, were not performed for data limitations.
Asian Pac J Cancer Prev. In addition, seven studies were excluded because the cases just were diagnosed oral cancer, were 1036 confirmed the identification of OSCC.
International Journal of Biological Sciences.
All relevant case-control studies were screened, irrespective of languages. 11306 results were in dependently screened by two authors according to the titles, abstracts and types of articles, and irrelevant papers were dropped out. How to cite this article: Kaohsiung J Med Sci. Glutathione S-transferase T1 gene deletion polymorphism and lung cancer risk in Chinese population: CYP1A1 genotypes and haplotypes and risk of oral cancer: Differences between reviewers were solved by discussion, or through consultation if necessary.
Overall, in spite of these limitations, the results of this analysis suggest that the ldi variant might be a risk factor of OSCC.
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A case-control study in South Indians. The cumulative z-curve does not cross the trial monitoring boundary before reaching the required power, which indicates that the cumulative evidence is insufficient and further trials are necessary Figure 3.
The following characteristic were collected from each study, ethnicity, country, sample size, control source, matching contents, the Hardy-Weinberg Equilibrium HWEand genetic distribution of cases and controls. Click on the image to enlarge. J Cancer ; 6 4: As for the other three models homozygous model, dominant model and allele comparing modelthey failed to show obvious association between CYP1A1 IleVal polymorphism and OSCC risk, and the heterogeneities among studies were observed in them, respectively.
Then we downloaded the relevant papers and further screened to identify potentially eligible studies. The scores of NOS ranges from zero the lowest to nine the highest stars, with more stars indicating a better methodological quality. Therefore, the study might only have limited statistical power. Pubmed, Web of Science, Ovid and Embase databases without language limitations, and the last research was updated on August 8, Gene polymorphisms, tobacco exposure and oral cancer susceptibility: Based on this issue, we applied the TSA to estimate the power of the current conclusions [ 32 – 34 ].
As shown in Figure 1a total of studies were retrieved by the literature search. The assessment was performed independently by two investigators and the inconformity was solved by a discussion, or consultation if necessary.
However, ‘the best available evidence’ might not be always equal to ‘sufficient evidence’. Genetic polymorphism of CYP genes, alone or lel combination, as a risk modifier of tobacco-related cancers. The research 110036 of human genome project HGP have demonstrated that different individuals are all Bias in meta-analysis detected by a simple, graphical test. Of the 13 studies included in this meta-analysis, eight studies were performed in Asians, four in Caucasians, and one in mixed race.
Journal of Genomics in PubMed Central. The inconsistency index I 2 was calculated to assess the variation caused by heterogeneity. Tobacco use and oral cancer: Apparently conclusive meta-analyses 10136 be inconclusive–Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data 11306 apparently conclusive neonatal meta-analyses.
After the subgroup analyses by ethnicity, source of control, HWE, the heterogeneities were not removed, indicating that other factors, such as age, gender, country, lifestyle, social status, smoking and alcohol habits might also yield to heterogeneities.
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Second, in the current meta-analysis, only 13 articles with cases and controls were included. Summaries of these studies were presented in Table 1 which included the first author, ethnicity, country, number and characteristics of cases and controls, and other relevant information. Hence, investigating the risk factors and developing the early diagnosis for treatment and prevention of OSCC are urgently needed.
Users should refer to the original published version of the material for the full abstract. For conflicting evaluation, an agreement was reached following a discussion.
Besides, six papers were excluded because of failing to provide sufficient data. Epidemiological studies showed that OSCC have been associated with high tobacco abuse and alcohol consumption [ 7 – 11 ]. However, the cases included in this research are OSCC and verrucous carcinoma.